{"id":4643,"date":"2024-11-28T03:17:25","date_gmt":"2024-11-28T03:17:25","guid":{"rendered":"https:\/\/www.echelecabeza.com\/?p=4643"},"modified":"2025-05-12T23:53:56","modified_gmt":"2025-05-12T23:53:56","slug":"trazodona","status":"publish","type":"post","link":"https:\/\/www.echelecabeza.com\/trazodona\/","title":{"rendered":"TRAZODONA"},"content":{"rendered":"<p><strong>Trazodona<\/strong><\/p>\n<p>La trazodona es un psicof\u00e1rmaco de uso principalmente cl\u00ednico para la depresi\u00f3n o desordenes de sue\u00f1o, inicialmente la trazodona fue clasificada como un antidepresivo at\u00edpico por la estructura qu\u00edmica y perfil farmacol\u00f3gico, referente a su mecanismo de acci\u00f3n se ha establecido que la trazodona act\u00faa como antagonista de los receptores serotonin\u00e9rgicos (5-HT2A y 5-HT2C) y adren\u00e9rgicos Alpha 1 y 2 lo cual puede ser el responsable de sus efectos sedativos (Urzola, H. 2015). Por otro lado, su metabolismo se caracteriza por tener una absorci\u00f3n entre la primera o segunda hora posterior a su administraci\u00f3n, este medicamento es altamente lipof\u00edlico y es bio-transormado principalmente por oxidaci\u00f3n hep\u00e1tica microsomal, adem\u00e1s se ha sugerido que la encima CYP-P450 est\u00e1 implicada en su metabolismo; se ha afirmado que la trazodona se metaboliza casi completamente debido a que menos del 1% es excretada sin cambios en la orina (Alcantara, G. Gutierrez, A., Hern\u00e1ndez, M. &amp; Contreras, M. 2009).<\/p>\n<p><strong>Efectos principales <\/strong><\/p>\n<p>-Sedaci\u00f3n<\/p>\n<p>-Inductor de sue\u00f1o<\/p>\n<p>-Disminuci\u00f3n de ansiedad<\/p>\n<p>-Disminuci\u00f3n de estados afectivos\/emocionales negativos<\/p>\n<p>-Hipnotico<\/p>\n<p><strong>Efectos secundarios<\/strong><\/p>\n<p>los efectos secundarios m\u00e1s frecuentes en el tratamiento con trazodona son somnolencia, mareo, n\u00e1usea y dolor de cabeza. Se ha reportado hepatoxicidad con la administraci\u00f3n prolongada de trazodona y a\u00fan a pocos d\u00edas de iniciado el tratamiento; asimismo, hay reportes de diston\u00eda tard\u00eda y s\u00edndrome sensorial tard\u00edo, as\u00ed como hiponatremia y crisis convulsivas por sobredosis (Alcantara, G. Gutierrez, A., Hern\u00e1ndez, M. &amp; Contreras, M. 2009).<\/p>\n<p><strong>Recomendaciones<\/strong><\/p>\n<p>-No mezclar con otras SPA, principalmente con alcohol.<\/p>\n<p>-No sobrepasar dosis mayores a las indicadas por el profesional y en casos recreacionales no sobrepasar los 150 mg[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La trazodona es un psicof\u00e1rmaco de uso principalmente cl\u00ednico para la depresi\u00f3n o desordenes de sue\u00f1o, inicialmente la trazodona fue clasificada como un antidepresivo at\u00edpico por la estructura qu\u00edmica y perfil farmacol\u00f3gico.<\/p>\n","protected":false},"author":3,"featured_media":4494,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[8],"tags":[],"class_list":["post-4643","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-info-sustancias"],"_links":{"self":[{"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/posts\/4643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/comments?post=4643"}],"version-history":[{"count":3,"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/posts\/4643\/revisions"}],"predecessor-version":[{"id":5649,"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/posts\/4643\/revisions\/5649"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/media\/4494"}],"wp:attachment":[{"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/media?parent=4643"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/categories?post=4643"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.echelecabeza.com\/wp-json\/wp\/v2\/tags?post=4643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}